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專利授權區

專利授權區
專利名稱(英)	POLYMER AND ITS PRODUCTION METHOD
專利家族	中華民國：202603018(公開號) 大陸：CN 120399267 A(公開號) 美國：US-2025-0243349-A1(公開號)
專利權人	國立清華大學 100.00%
發明人	江安世,王志光,劉柏亨,徐克臻,張煒堃,莊凱翔,林慧貞,吳明親
技術領域	材料化工,生化醫藥

專利摘要(中)
本揭露提供的聚合物以及其製作方法，以HAMA來改質水凝膠，改質後的水凝膠擁有不易碎裂的特性，並且其強度適中能夠用於切割掃描。改質後的水凝膠搭配迭代擴張顯微術(iExM)的技術能夠達到六十倍以上的放大倍率。如此一來，改質放大後後水凝膠樣本能夠被切割進行逐層的顯微觀察，使擴張顯微技術的應用不再受限於樣本過大無法在有限的工作距離操作，因此提高擴張顯微技術的應用範圍，進而對生物組織以此新穎的iExM改質水凝膠系統可進一步達到近數十奈米解析尺度，以了解更多生物組織的微結構與奧秘，從而對生物的結構與生理有更深入的了解。

專利摘要(中)

本揭露提供的聚合物以及其製作方法，以HAMA來改質水凝膠，改質後的水凝膠擁有不易碎裂的特性，並且其強度適中能夠用於切割掃描。改質後的水凝膠搭配迭代擴張顯微術(iExM)的技術能夠達到六十倍以上的放大倍率。如此一來，改質放大後後水凝膠樣本能夠被切割進行逐層的顯微觀察，使擴張顯微技術的應用不再受限於樣本過大無法在有限的工作距離操作，因此提高擴張顯微技術的應用範圍，進而對生物組織以此新穎的iExM改質水凝膠系統可進一步達到近數十奈米解析尺度，以了解更多生物組織的微結構與奧秘，從而對生物的結構與生理有更深入的了解。

專利摘要(英)
A polymer and its production method provided by the disclosure use HAMA to modify the hydrogel. The modified hydrogel has properties of being insusceptible to breaking and has moderate strength for cutting and scanning. The modified hydrogel combined with iExM’s technology may achieve a magnification of 60 times or more. In this way, the modified and expanded hydrogel sample may be cut for performing a layer-by-layer microscopic observation, so that the application of expansion microscopy is no longer limited by samples that are too large to be operated within the limited working distance, the application scope of expansion microscopy may be improved, and the novel iExM modified hydrogel system may be further applied to biological tissues to achieve a resolution scale of nearly tens of nanometers, so as to gain insight into the microstructure and mysteries of biological tissues and a deeper understanding of the structure and physiology of organisms.

專利摘要(英)

A polymer and its production method provided by the disclosure use HAMA to modify the hydrogel. The modified hydrogel has properties of being insusceptible to breaking and has moderate strength for cutting and scanning. The modified hydrogel combined with iExM’s technology may achieve a magnification of 60 times or more. In this way, the modified and expanded hydrogel sample may be cut for performing a layer-by-layer microscopic observation, so that the application of expansion microscopy is no longer limited by samples that are too large to be operated within the limited working distance, the application scope of expansion microscopy may be improved, and the novel iExM modified hydrogel system may be further applied to biological tissues to achieve a resolution scale of nearly tens of nanometers, so as to gain insight into the microstructure and mysteries of biological tissues and a deeper understanding of the structure and physiology of organisms.

聯絡資訊
承辦人姓名	李佳玲
承辦人電話	03-5715131 #62300
承辦人Email	cl.lee@mx.nthu.edu.tw