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專利名稱(中)	聚乙二醇化硼色胺酸衍生物及其製備方法、包含聚乙二醇化硼色胺酸衍生物的醫藥組成物及其用於治療腫瘤與用於正子斷層造影掃描以評估腫瘤之硼中子捕獲治療之藥物動力學並且定量以計算藥物動力學之藥物濃度的用途
專利名稱(英)	PEGYLATED BORONOTRYPTOPHAN DERIVATIVE AND PREPARATION PROCESS THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING PEGYLATED BORONOTRYPTOPHAN DERIVATIVE AND USE OF PEGYLATED BORONOTRYPTOPHAN DERIVATIVE FOR TREATING TUMOR AND FOR PET SCANNING FOR ASSESSING PHARM
專利家族	中華民國：I888094 大陸：CN 120641464 A(公開號)
專利權人	國立清華大學 100.00%
發明人	俞鐘山
技術領域	生化醫藥

專利摘要(中)
本發明提供一種聚乙二醇化硼色胺酸衍生物及其製備方法、包含聚乙二醇化硼色胺酸衍生物的醫藥組成物及其用於治療腫瘤與用於正子斷層造影掃描以評估腫瘤之硼中子捕獲治療之藥物動力學並且定量以計算藥物動力學之藥物濃度的用途。本發明聚乙二醇化硼色胺酸衍生物及包含聚乙二醇化硼色胺酸衍生物的醫藥組成物藉由多種功效實驗，達到治療腫瘤及用於正子斷層造影掃描以評估腫瘤之硼中子捕獲治療之藥物動力學並且定量以計算藥物動力學之藥物濃度之效果。

專利摘要(中)

本發明提供一種聚乙二醇化硼色胺酸衍生物及其製備方法、包含聚乙二醇化硼色胺酸衍生物的醫藥組成物及其用於治療腫瘤與用於正子斷層造影掃描以評估腫瘤之硼中子捕獲治療之藥物動力學並且定量以計算藥物動力學之藥物濃度的用途。本發明聚乙二醇化硼色胺酸衍生物及包含聚乙二醇化硼色胺酸衍生物的醫藥組成物藉由多種功效實驗，達到治療腫瘤及用於正子斷層造影掃描以評估腫瘤之硼中子捕獲治療之藥物動力學並且定量以計算藥物動力學之藥物濃度之效果。

專利摘要(英)
The present disclosure provides a PEGylated boronotryptophan derivative and the preparation process thereof, a pharmaceutical composition including the PEGylated boronotryptophan derivative, and uses of the PEGylated boronotryptophan derivative for treating tumor and for PET scanning for assessing pharmacokinetics for boron neutron capture therapy of tumors and quantifying drug concentrations to calculate pharmacokinetics. The PEGylated boronotryptophan derivative and the pharmaceutical composition including the PEGylated boronotryptophan derivative of the present disclosure achieve the effect of treating tumor and being used for PET scanning for assessing the pharmacokinetics for boron neutron capture therapy of tumors and quantifying drug concentrations to calculate pharmacokinetics through various efficacy experiments.

專利摘要(英)

The present disclosure provides a PEGylated boronotryptophan derivative and the preparation process thereof, a pharmaceutical composition including the PEGylated boronotryptophan derivative, and uses of the PEGylated boronotryptophan derivative for treating tumor and for PET scanning for assessing pharmacokinetics for boron neutron capture therapy of tumors and quantifying drug concentrations to calculate pharmacokinetics. The PEGylated boronotryptophan derivative and the pharmaceutical composition including the PEGylated boronotryptophan derivative of the present disclosure achieve the effect of treating tumor and being used for PET scanning for assessing the pharmacokinetics for boron neutron capture therapy of tumors and quantifying drug concentrations to calculate pharmacokinetics through various efficacy experiments.

聯絡資訊
承辦人姓名	楊慧敏
承辦人電話	(03)571-5131 #31181
承辦人Email	hmyang@mx.nthu.edu.tw