The present invention provides a polypeptide adjuvant composition with thermostability, which is designed from wild-type chicken interleikin-1.beta. to construct a new chicken interleikin-1.beta., named CP-interleikin-1.beta.. The CP-interleikin-1.beta. having improved heat resistance keeps the original biological activity, and which helps to develop protein adjuvant with high efficiency and uses in medical application. The present invention also provides a method of manufacturing such polypeptide adjuvant composition. |