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專利授權區

專利授權區
專利名稱(英)	CLINICAL PATHOLOGIC DATA-FREE AND COMPUTER-AIDED PREDICTION SYSTEM FOR GENETIC VARIATION PATHOGENICITY AND INHERITANCE PATTERN THEREOF AND METHOD THEREOF, AND ION SELECTION SYSTEM AND METHOD THEREOF
專利家族	中華民國：I888276 美國：US 2026-0081030 A1(公開號)
專利權人	國立清華大學 20.00% ,國立臺灣大學醫學院附設醫院新竹臺大分院 80.00%
發明人	蔡政育,吳振吉,楊立威
技術領域	生化醫藥,資訊工程

專利摘要(英)
A clinical pathologic data-free and computer-aided prediction method for genetic variation pathogenicity and an inheritance pattern thereof includes a molecular dynamics (MD) simulation step, a computing step, a determination step, and a predicted result production step. The MD simulation step is to perform molecular modeling and computational simulations on channel protein configurations, where the channel protein configurations include a wild-type channel or mutated channels. The computing step is to compute the number of ions passing through the wild-type channel and the number of ions passing through the mutated channel, respectively to obtain a first ion number and a second ion number within a predetermined period. The determination step is to determine the class of each mutated channel according to the first ion number and the second ion number. The predicted result production step is to produce a predicted result according to the classes of the mutated channels.

專利摘要(英)

A clinical pathologic data-free and computer-aided prediction method for genetic variation pathogenicity and an inheritance pattern thereof includes a molecular dynamics (MD) simulation step, a computing step, a determination step, and a predicted result production step. The MD simulation step is to perform molecular modeling and computational simulations on channel protein configurations, where the channel protein configurations include a wild-type channel or mutated channels. The computing step is to compute the number of ions passing through the wild-type channel and the number of ions passing through the mutated channel, respectively to obtain a first ion number and a second ion number within a predetermined period. The determination step is to determine the class of each mutated channel according to the first ion number and the second ion number. The predicted result production step is to produce a predicted result according to the classes of the mutated channels.

聯絡資訊
承辦人姓名	黃允恬
承辦人電話	(03)571-5131#62305
承辦人Email	yuntian@mx.nthu.edu.tw