A selective bit-line sensing method is disclosed. The selective bit-line sensing method includes the steps of: generating a neuron weights information, the neuron weights information defines a distribution of 0’s and 1’s storing in the plurality of memory cells of the memory array; and selectively determining either the plurality of bit-lines or the plurality of complementary bit-lines to be sensed in a sensing operation according to the neuron weights information. When the plurality of bit-lines are determined to be sensed, the plurality of first word-lines are activated by the artificial neural network system through the selective bit-line detection circuit, and when the plurality of complementary bit-lines are determined to be sensed, the plurality of second word-lines are activated by the artificial neural network system. |