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專利授權區
專利名稱(中) 循序崩解之帶殼多胜肽奈米載體及其製備方法
專利名稱(英) SEQUENTIALLY DECOMPOSABLE POLYPEPTIDE-BASED NANOCARRIERS WITH PROTECTIVE SHELL AND PREPARATION THEREOF
專利家族 中華民國:I601536
美國:US 10,905,653
專利權人 國立清華大學 100%
發明人 王俐雯,王子威
技術領域 材料化工,生化醫藥
專利摘要(中)
Provided is a sequentially decomposable polypeptide-based nanocarrier with protective shell for delivery of hydrophobic drugs and preparation thereof. The nanocarrier comprises a polypeptide-based long chain copolymer and a polypeptide-based short chain copolymer both assembling into an outer layer of hydrophilic polymer and a polypeptide core, wherein the polypeptide-based long chain copolymer comprises a long-chain hydrophilic polymer and a first polypeptide chain; the polypeptide-based short chain copolymer comprises a short-chain hydrophilic polymer and a second polypeptide chain; the first and the second polypeptide chains each sequentially comprises an acidic amino acid segment, an acid-responsive amino acid segment, and a hydrophobic amino acid segment; the long-chain hydrophilic polymer is conjugated with the first polypeptide chain via an acid-labile linkage; an end of the short-chain hydrophilic polymer is conjugated with an active targeting molecule; and the polypeptide core comprises a protective shell of an acid-soluble mineral on the acidic amino acid segment.
聯絡資訊
承辦人姓名 蔡昀臻
承辦人電話 03-5715131 #31036
承辦人Email yunchen@mx.nthu.edu.tw
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