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專利授權區
專利名稱(中) 口服藥物組成物及其用途
專利名稱(英) ORAL DRUG COMPOSITION AND USES THEREOF
專利家族 中華民國:202110484(公開號)
美國:US-2021-0069344-A1(公開號)
專利權人 國立清華大學 100%
發明人 宋信文,繆養寶,陳冠宏
技術領域 生化醫藥
專利摘要(中)
本發明提供一種口服藥物組成物,其包含一前體藥物以及一載體。所述前體藥物係由一活性藥物與一間隔物以共價鍵連接所形成。所述載體承載有效量之前體藥物,其中所述載體包含β-1,3-D-葡聚醣。藉此,前述口服藥物組成物可靶向腸道的微皺褶細胞,使本發明之口服藥物組成物以膜吞噬模式有效地跨上皮運輸以突破黏膜屏障傳遞至所需位置,並可用於製備抗癌的藥物。
專利摘要(英)
The invention relates to an oral drug composition including a prodrug and a carrier. The prodrug is formed by covalent bonding of an active drug to a spacer. The carrier includes β-1,3-D-glucan and is provided for carrying the prodrug with an efficient amount. Therefore, the oral drug composition can target microfold cells of the intestinal tract, allowing the oral drug composition of the present invention to effectively transport across the intestinal epithelium in a membrane phagocytic mode to break through the mucosal barrier to the desired location. Thus, the oral drug composition can be used to prepare anticancer drugs.
聯絡資訊
承辦人姓名 呂建潁
承辦人電話 03-5715131 #31061
承辦人Email chienying_lu@mx.nthu.edu.tw
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