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專利授權區
專利名稱(中)	模擬腹腔熱化療之藥物篩選平台
專利名稱(英)	Drug screening platform simulating hyperthermic intraperitoneal chemotherapy
專利家族	中華民國：I795812 大陸：CN 115491300 A(公開號) 美國：11,712,696
專利權人	國立清華大學 100%
發明人	劉承賢,趙得宇,童俞靜,謝茂志,戴裕庭,何秉穎,張偉嶠,魏頌揚,謝長宏,周忠誠,計仁昌,徐琅,張晃猷,陳皇銘
技術領域	生化醫藥,機械結構,電子電機

專利摘要(英)
A drug screening platform simulating hyperthermic intraperitoneal chemotherapy including a dielectrophoresis system, a microfluidic chip and a heating system is disclosed. The dielectrophoresis system is used to provide a dielectrophoresis force. The microfluidic chip includes a cell culture array ＆ observation module and a drug mixing module. The cell culture array ＆ observation module is used to arrange the cells into a three-dimensional structure through the dielectrophoresis force to construct a three-dimensional tumor microenvironment. The drug mixing module is coupled to the cell culture array ＆ observation module and used to automatically split and mix the inputted drugs and output the drug combinations into the cell culture array ＆ observation module. The heating system is used for real-time temperature sensing and heating control of the drug combinations on the microfluidic chip to simulate high-temperature drug environment when performing hyperthermic intraperitoneal chemotherapy on the three-dimensional tumor microenvironment.

專利摘要(英)

A drug screening platform simulating hyperthermic intraperitoneal chemotherapy including a dielectrophoresis system, a microfluidic chip and a heating system is disclosed. The dielectrophoresis system is used to provide a dielectrophoresis force. The microfluidic chip includes a cell culture array ＆ observation module and a drug mixing module. The cell culture array ＆ observation module is used to arrange the cells into a three-dimensional structure through the dielectrophoresis force to construct a three-dimensional tumor microenvironment. The drug mixing module is coupled to the cell culture array ＆ observation module and used to automatically split and mix the inputted drugs and output the drug combinations into the cell culture array ＆ observation module. The heating system is used for real-time temperature sensing and heating control of the drug combinations on the microfluidic chip to simulate high-temperature drug environment when performing hyperthermic intraperitoneal chemotherapy on the three-dimensional tumor microenvironment.

聯絡資訊
承辦人姓名	劉千綺
承辦人電話	03-571-5131 #31181
承辦人Email	chienchi@mx.nthu.edu.tw