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專利授權區
專利名稱(中)	模擬腹腔熱化療之藥物篩選平台
專利名稱(英)	Drug screening platform simulating hyperthermic intraperitoneal chemotherapy
專利家族	中華民國：I795812 大陸：CN 115491300 A(公開號) 美國：11,712,696
專利權人	國立清華大學 100.00%
發明人	劉承賢,趙得宇,童俞靜,謝茂志,戴裕庭,何秉穎,張偉嶠,魏頌揚,謝長宏,周忠誠,計仁昌,徐琅,張晃猷,陳皇銘
技術領域	生化醫藥,機械結構,電子電機

專利摘要(中)
本發明揭露一種模擬腹腔熱化療之藥物篩選平台，包括介電泳系統、微流道晶片及加熱系統。介電泳系統用以提供介電泳力。微流道晶片包括細胞培養陣列及觀察模組與藥物混合模組。細胞培養陣列及觀察模組用以透過介電泳力使細胞排列成三維結構，以建構三維腫瘤微環境。藥物混合模組耦接至細胞培養陣列及觀察模組，用以自動將輸入之複數種藥物分流及混合後輸出複數種藥物組合至細胞培養陣列及觀察模組。加熱系統用以對微流道晶片上的該複數種藥物組合進行即時溫度感測及加熱控制，以模擬對三維腫瘤微環境進行腹腔熱化療時之高溫藥物環境。

專利摘要(中)

本發明揭露一種模擬腹腔熱化療之藥物篩選平台，包括介電泳系統、微流道晶片及加熱系統。介電泳系統用以提供介電泳力。微流道晶片包括細胞培養陣列及觀察模組與藥物混合模組。細胞培養陣列及觀察模組用以透過介電泳力使細胞排列成三維結構，以建構三維腫瘤微環境。藥物混合模組耦接至細胞培養陣列及觀察模組，用以自動將輸入之複數種藥物分流及混合後輸出複數種藥物組合至細胞培養陣列及觀察模組。加熱系統用以對微流道晶片上的該複數種藥物組合進行即時溫度感測及加熱控制，以模擬對三維腫瘤微環境進行腹腔熱化療時之高溫藥物環境。

專利摘要(英)
A drug screening platform simulating hyperthermic intraperitoneal chemotherapy including a dielectrophoresis system, a microfluidic chip and a heating system is disclosed. The dielectrophoresis system is used to provide a dielectrophoresis force. The microfluidic chip includes a cell culture array ＆ observation module and a drug mixing module. The cell culture array ＆ observation module is used to arrange the cells into a three-dimensional structure through the dielectrophoresis force to construct a three-dimensional tumor microenvironment. The drug mixing module is coupled to the cell culture array ＆ observation module and used to automatically split and mix the inputted drugs and output the drug combinations into the cell culture array ＆ observation module. The heating system is used for real-time temperature sensing and heating control of the drug combinations on the microfluidic chip to simulate high-temperature drug environment when performing hyperthermic intraperitoneal chemotherapy on the three-dimensional tumor microenvironment.

專利摘要(英)

A drug screening platform simulating hyperthermic intraperitoneal chemotherapy including a dielectrophoresis system, a microfluidic chip and a heating system is disclosed. The dielectrophoresis system is used to provide a dielectrophoresis force. The microfluidic chip includes a cell culture array ＆ observation module and a drug mixing module. The cell culture array ＆ observation module is used to arrange the cells into a three-dimensional structure through the dielectrophoresis force to construct a three-dimensional tumor microenvironment. The drug mixing module is coupled to the cell culture array ＆ observation module and used to automatically split and mix the inputted drugs and output the drug combinations into the cell culture array ＆ observation module. The heating system is used for real-time temperature sensing and heating control of the drug combinations on the microfluidic chip to simulate high-temperature drug environment when performing hyperthermic intraperitoneal chemotherapy on the three-dimensional tumor microenvironment.

聯絡資訊
承辦人姓名	劉千綺
承辦人電話	03-571-5131 #31181
承辦人Email	chienchi@mx.nthu.edu.tw